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Multivariate Metal–Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules

Zhiyue Dong,  Yangzesheng Sun,  Jun Chu,  Xianzheng Zhang, and Hexiang Deng*

Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences, and  UC Berkeley-Wuhan University Joint Innovative Center, The Institute of Advanced Studies,   Wuhan University, Luojiashan, Wuhan 430072,   China      

J. Am. Chem. Soc.,  2017,  139 (40), pp 14209–14216  

DOI: 10.1021/jacs.7b07392  

Publication Date (Web): September 12, 2017  

Copyright © 2017 American Chemical Society  



Abstract Image                        

We report the control of guest release profiles by dialing-in desirable interactions between guest molecules and pores in metal–organic frameworks (MOFs). The interactions can be derived by the rate constants that were quantitatively correlated with the type of functional group and its proportion in the porous structure; thus the release of guest molecules can be predicted and programmed. Specifically, three probe molecules (ibuprofen, rhodamine B, and doxorubicin) were studied in a series of robust and mesoporous MOFs with multiple functional groups [MIL-101(Fe)-(NH2)x, MIL-101(Fe)-(C4H4)x, and MIL-101(Fe)-(C4H4)x(NH2)1–x]. The release rate can be adjusted by 32-fold [rhodamine from MIL-101(Fe)-(NH2)x], and the time of release peak can be shifted by up to 12 days over a 40-day release period [doxorubicin from MIL-101(Fe)-(C4H4)x(NH2)1–x], which was not obtained in the physical mixture of the single component MOF counterparts nor in other porous materials. The corelease of two pro-drug molecules (ibuprofen and doxorubicin) was also achieved.

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