Title：Routes to N-glycinamideoxazolidinone derivatives: The reaction of 4- trityloxymethyl-3-oxa-1-azabicyclo[3.1.0]hexan-2-one with active halides
Lecturer：Doctor Zilong Zheng
Time：3:00p.m. ,June 28th,2019(Friday)
Place：VIP Room at first floor, Chemistry Building(West)
Abstract：
N-Glycinamideoxazolidinones are key intermediates for the synthesis of a new class of peptidomimetics. We present herein the synthesis of a series of 3,4,5-trisubstituted oxazolidinones with a glycine residue at N-3 of the oxazolidinone ring. Substituents at C-4 and C-5 contain substitution capabilities which are amenable for the introduction of additional peptide chains. The synthesis of the key N-Glycinamideoxazolidinone is made possible through two reactions; a tandem aziridine ring opening/oxazolidinone alkylation and, subsequently, a fused-lactone ring opening by an amine which leads to the N-Glycinamideoxazolidinones.
About the lecturer：
Dr. Zilong Zheng has successively worked in the research group of Academician Shengming Ma in the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, and the Nobel Prize winner Professor Negishi in the University of Purdue, and the United States Promiliad Biopharma Incorporated, Basilea Pharmaceutical (China) Co., Ltd. Dr. Zilong Zheng has published 8 articles in J. Am. Chem. Soc., Angew. Chem. Int. Ed. and other journals, citing about 500 times. Dr. Zilong Zheng is concerned about education. During his stay in the United States, he has sponsored several undergraduates majoring in chemistry, physics and mathematics to study for doctoral degrees in the United States.
