Professor Cai Jie and his team from the College of Chemistry and Molecular Sciences at Wuhan University have made significant progress in chitosan-based biomaterials.

Their research has been published in leading international journals, including Advanced Materials and Bioactive Materials, and a comprehensive review has been featured in Scientia Sinica Chimica.

These publications highlight the team's comprehensive academic trajectory, from fundamental research on green solvents to the development of oriented functional materials, showcasing a strong focus on translational research addressing major medical needs.

Coagulation-independent hemostasis through architecturally programmed chitosan aerogels with dual-crosslinked networks, published in Advanced Materials, introduces an innovative "architecturally programmable" material design. The team developed chitosan aerogels with hierarchical pore structures using ice-templating and dual-crosslinking strategies, proposing a dual-crosslinked hierarchical capillary-elastic memory (DC-HCEM) hemostatic mechanism.

Engineering multifunctional chitosan-based hydrogels for integrated antimicrobial therapy and endogenous stem cell-driven tissue repair in infectious keratitis, published in Bioactive Materials, offers a new approach for the integrated treatment of infectious ocular surface diseases.

Their review in Scientia Sinica Chimica summarizes the dissolution mechanisms and functional material regulation strategies of three green solvent systems: ionic liquids, deep eutectic solvents, and alkaline aqueous solutions, providing theoretical support for clinically oriented material research.